PO-03-093 EFFECT OF CATHETER ABLATION FOR ATRIAL FIBRILLATION ON LEFT ATRIAL FUNCTION AND LEFT VENTRICULAR DIASTOLIC FILLING

Medium to long term effects of catheter ablation (CA) on left atrial (LA) function in patients with paroxysmal fibrillation (AF) using cardiac magnetic resonance (CMR) are not well studied. Moreover, the changes ventricular(LV) diastolic filling patterns (by CMR) after CA have been To assess medium-term LA and LV CMR. We analysed consecutive undergoing for AF at our institution from 2020-2022. Only who had both pre post CMR were sinus rhythm time included. Patients underwent late gadolinium enhancement cine sequence functional structural assessment. Left ventricular analysis was done endocardial border tracking create time-volume curves, while fibrosis assessed as a percentage total wall area stratified by Utah stage. (LAEF), active (LA-AEF), passive (LA-PEF) emptying fractions expansion index (LA-EI) calculated maximum, minimum before contraction volumes. Early peak rate (EPFR) rates (APFR) derived volume loops. Multivariate performed effect change LAEF. Of 33 included, 45.5% female mean age 64.8 ± 9.4 years. Mean 4.5 2.5 months. Baseline LAEF 35.7 8.3% 15.5 6.5% (Table 1A). Post reduction LAEF, 16.7% LA-EI, 6.8% LA-AEF 1.7% LA-PEF (all p < 0.05). also showed significant 21.2% increase EPFR 15.7% decrease APFR (p 0.05) 1B). On multivariate adjusting age, sex, CHADSVASC, fibrosis, CMR, only predictor (HR 1.34 0.74-1.94 At medium follow up, is associated parameters filling. This maybe due distensibility which reflected faster early LV. could allude an pressure occuring AF. may predict ablation.Tabled 1Pre Ablation parametersVariablePre AblationPost AblationP valueLAV Max (Ml/m2)45.9 12.943.4 12.10.004LAV Min (Ml/m2)29.9 10.831.1 10.30.203LA-BAC (Ml/m2)37.9 11.836.6 11.20.14LA-EF %35.7 8.329.3 6.9<0.00001LA-EI %58.5 21.741.8 14.2<0.00001LA-AEF %22.1 6.115.7 5.6<0.00001LA-PEF %17.8 5.816.1 4.10.03EPFR/LVEDV (s-1)2.6 0.633.1 0.50.002APFR/LVEDV (s-1)2.01 0.51.7 0.60.0001LA-Left atrium, BAC-Before Atrial Contraction, EF-emptying fraction, EI-Expansion index, AEF- Active PEF-Passive EPFR-Early rate, APFR-Atrial LVEDV-left end Open table new tab